This web page was produced as an assignment for Gen677, an undergraduate course at UW-Madison Spring 2009
Phylogenetic Analysis
This tree was generated using TreeDyn and the alignment from ClustalW.
This tree was generated using TreeTop and the ClustalW alignment. Interestingly, they produce different results for which species of SORL1 are most closely related. The TreeDyn tree shows mouse and rat being most closely related, while the TreeTop version has mouse being most closely related to human SORL1. In fact, TreeTop has a large distance between rat and mouse. This is interesting because in these diagrams there appears to be a large difference in the proteins, whereas when you look at the sequence, they are all quite similar.
References
Dereeper A.*, Guignon V.*, Blanc G., Audic S., Buffet S., Chevenet F., Dufayard J.F., Guindon S., Lefort V., Lescot M., Claverie J.M., Gascuel O. Phylogeny.fr: robust phylogenetic analysis for the non-specialist. Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W465-9. Epub 2008 Apr 19. (PubMed) *: joint first authors
Edgar RC. MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res. 2004, Mar 19;32(5):1792-7. (PubMed)
Castresana J. Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. Mol Biol Evol. 2000, Apr;17(4):540-52. (PubMed)
Guindon S., Gascuel O. A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst Biol. 2003, Oct;52(5):696-704. (PubMed)
Anisimova M., Gascuel O. Approximate likelihood ratio test for branchs: A fast, accurate and powerful alternative. Syst Biol. 2006, Aug;55(4):539-52. (PubMed)
Chevenet F., Brun C., Banuls AL., Jacq B., Chisten R. TreeDyn: towards dynamic graphics and annotations for analyses of trees. BMC Bioinformatics. 2006, Oct 10;7:439. (PubMed)
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Last Updated 5/13/09
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